Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

BPC-157 10mg

BPC-157 is a pentadecapeptide composed of 15 amino acids. It is a partial sequence of Body Protection Compound, or BPC, a peptide originally identified in human gastric juice. BPC-157 has been widely studied in animal models for its potential role in tissue repair, wound healing, gastrointestinal protection, and recovery-related biological pathways.

Research has explored BPC-157 for its potential effects on the healing of muscles, tendons, ligaments, skin wounds, burns, and other damaged tissues. Studies suggest it may support angiogenesis, also known as new blood vessel formation, while also promoting collagen and reticulin production. These processes are important for tissue strength, structural repair, and proper wound closure.

Because of its involvement in vascular growth, connective tissue remodeling, and gastrointestinal protection, BPC-157 remains an area of interest in research focused on wound healing, tissue recovery, inflammation response, and injury-related repair mechanisms.

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1. What Is BPC-157?

2. BPC-157 Peptide Structure

3. BPC-157 Peptide Research

4. Future BPC-157 Research

5. Referenced Citations

What Is BPC-157? A Research Overview

BPC-157, short for Body Protection Compound-157, is a synthetic pentadecapeptide made up of 15 amino acids. It is derived from Body Protection Compound, a naturally occurring protein found in the human digestive tract that has been studied for its role in protecting the gastrointestinal lining, supporting tissue repair, and promoting blood vessel formation.

Although BPC-157 is only a smaller fragment of the larger BPC protein, research suggests that it may retain many of the parent compound’s repair-related properties. Studies have explored BPC-157 for its potential effects on wound healing, gastrointestinal protection, connective tissue repair, angiogenesis, inflammation regulation, and recovery following injury.

In particular, BPC-157 has been studied for its potential influence on:

Research has examined BPC-157 for its potential role in several biological pathways, including:

Tissue repair and wound recovery
Formation of new blood vessels
Blood-clotting and coagulation processes
Nitric oxide signaling
Immune response regulation
Gene activity and cellular signaling
Hormonal signaling within the gastrointestinal nervous system

BPC-157 Peptide Structure

Sequence: Gly- Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1419.556 g/mol
PubChem CID: 108101

BPC-157 Research Overview

How BPC-157 May Support Wound Healing and Tissue Repair

The natural role of Body Protection Compound, or BPC, within the gastrointestinal tract is to help maintain the integrity of the mucosal barrier. This barrier protects underlying tissues from gastric acid, bile, digestive enzymes, and other compounds involved in digestion and nutrient absorption.

Research suggests that BPC-157 may support this protective function in part by influencing fibroblast activity. Fibroblasts are key repair cells involved in collagen production, extracellular matrix formation, and wound closure.

Studies have shown that BPC-157 may have a dose-dependent effect on fibroblast behavior, helping these cells proliferate and migrate more efficiently in both cell culture and animal models. This increased fibroblast activity may contribute to faster tissue repair, improved wound closure, and stronger structural remodeling during the healing process.

BPC-157 May Support Angiogenesis and Vascular Repair

BPC-157 has been studied as a potential angiogenic peptide, meaning it may support the formation and growth of new blood vessels. Research suggests that BPC-157 can increase the proliferation and activity of endothelial cells, the cells that line the inside of blood vessels and play a central role in vascular repair. [1]–[3]

Animal studies in rats show that BPC-157 may significantly increase collateral blood vessel growth in models of ischemia, a condition where tissue receives reduced blood flow and oxygen. While much of this research has focused on the gastrointestinal tract, additional studies suggest that similar vascular-supporting effects may also be relevant in cardiovascular, neurological, and muscle tissue models. [4]–[6]

Because of these effects, BPC-157 remains an area of interest in research related to ischemic injury, tissue repair, stroke, heart attack, and blood-flow restoration. It is also being studied as a tool for better understanding how the body promotes healing after oxygen-deprivation injuries.

Some research suggests that BPC-157 may support vascular growth through the VEGFR2 pathway, a cell-surface receptor involved in nitric oxide signaling. VEGFR2 plays an important role in endothelial cell growth, proliferation, survival, and long-term vascular function. Studies in chicken embryo models suggest that activation of this pathway may be one mechanism behind BPC-157’s angiogenic effects. [4] [7] [8]

How BPC-157 May Support Angiogenesis and Vascular Repair

Cell culture research has demonstrated that BPC-157 may support a process sometimes described as vascular “running.” This refers to the growth and redirection of blood vessels toward injured tissue or around areas of vascular blockage in an effort to restore blood flow and protect downstream cell function. [9]

This vascular-supporting effect has made BPC-157 an area of interest in research involving ischemia, arterial occlusion, and impaired circulation. By encouraging collateral vessel growth, BPC-157 may help the body create alternative blood-flow pathways when normal circulation is restricted.

Researchers have speculated that this mechanism could one day contribute to new approaches for slow-developing arterial blockages, such as those seen in atherosclerotic cardiovascular disease. While much more research is needed, these findings suggest that BPC-157 may offer a useful model for studying how to promote vascular repair, improve tissue perfusion, and support recovery after reduced blood flow.

How BPC-157 May Support Tendon and Ligament Repair

Given its role in fibroblast activity and blood vessel formation, BPC-157 has been studied in animal models involving tendon, ligament, bone, and other connective tissue injuries. These tissues are often slow to heal because they have limited blood supply, which can restrict the delivery of fibroblasts and other repair-related cells to the injured area.

Research in both cell culture and rat tendon models suggests that BPC-157 may support collateral blood vessel formation and increase fibroblast density in injured connective tissue. These effects may help improve the repair environment and promote stronger tissue recovery. Some studies have reported that BPC-157 may be more effective than certain growth factors, including bFGF, EGF, and VEGF, in supporting healing within these tissue models. [10]

Additional experiments using FITC-phalloidin staining have shown that BPC-157 may stimulate F-actin formation in fibroblasts. F-actin is an important structural protein involved in cell shape, movement, and migration, all of which are essential for wound healing and tissue repair. [11]

Western blot analysis has also shown that BPC-157 may increase phosphorylation of paxillin and FAK proteins, which are key components of the cell-migration pathway. By supporting these pathways, BPC-157 may help fibroblasts move more efficiently into areas of injury, contributing to tendon, ligament, and connective tissue repair. [12]

How BPC-157 May Support Antioxidant and Cellular Protection Pathways

Research in rat models suggests that BPC-157 may help reduce oxidative stress by influencing markers such as nitric oxide and malondialdehyde, also known as MDA. MDA is commonly used as a marker of lipid peroxidation, which occurs when free radicals damage cell membranes. [3]

These findings suggest that BPC-157 may have antioxidant-like properties, particularly in tissues exposed to inflammation, injury, or metabolic stress. Additional research has shown that BPC-157 may help reduce the production of reactive oxygen species within the gastrointestinal tract, further supporting its potential role in cellular protection and tissue repair.

Researchers have also explored delivery methods for BPC-157 within the digestive system. One study investigated whether modified Lactococcus lactis bacteria could be used to deliver BPC-157 to the gastrointestinal tract. In cell culture, this approach significantly increased peptide levels, suggesting a potential research pathway for targeted GI delivery. [13]

Together, these findings make BPC-157 an area of interest in oxidative stress, gastrointestinal protection, antioxidant defense, and injury-repair research.

How BPC-157 May Help Reduce Drug-Related Side Effects

In many areas of pharmaceutical research, side effects can limit how long or how safely certain medications may be used. For example, NSAIDs such as ibuprofen are commonly studied for their pain-relieving and anti-inflammatory effects, but long-term use may be associated with gastrointestinal irritation, gastric bleeding risk, and cardiovascular concerns.

Because of this, researchers have long been interested in compounds that may help reduce medication-related tissue damage while preserving the intended therapeutic effects of the original drug. This type of protective support is a major focus in modern drug-safety research.

BPC-157 has been studied for its potential ability to counteract certain drug-related side effects in research models. Studies have explored its effects in relation to NSAID-associated tissue injury, medications used in psychiatric research, and several cardiovascular drug models.

These findings suggest that BPC-157 may support protective pathways involving the gastrointestinal tract, blood vessels, inflammation regulation, oxidative stress, and tissue repair. As a result, BPC-157 remains an area of interest in research focused on medication-related injury, drug tolerance, and protective support during pharmaceutical exposure.

It is not surprising that BPC-157 has been studied for its potential to reduce gastrointestinal side effects associated with certain medications. However, research also suggests that its protective effects may extend beyond the digestive system to tissues such as the brain, heart, and nervous system.

In rat studies, BPC-157 has been shown to protect against QTc prolongation, a heart rhythm abnormality that can increase the risk of serious and potentially fatal arrhythmias. QTc prolongation may occur with certain medications, including drugs used in diabetes management, schizophrenia, and other psychiatric conditions. [14]

BPC-157 has also been studied for its potential to reduce side effects linked to psychiatric medications, including severe reactions such as catalepsy and somatosensory disturbances. These findings are especially interesting because psychiatric treatment can be difficult to maintain when side effects are intense enough to cause patients to stop therapy. [15]

By supporting protective pathways in the gastrointestinal tract, cardiovascular system, and central nervous system, BPC-157 remains an area of interest in research focused on medication tolerance, drug-induced tissue stress, and side-effect reduction.

How BPC-157 May Support Bee Health Research

Colony collapse disorder, or CCD, is a condition in which honey bee colonies experience rapid decline that can eventually lead to complete hive loss. The causes of CCD are not fully understood, but one contributing factor may be infection of the honey bee gastrointestinal tract by the fungus Nosema ceranae.

Research has explored whether BPC-157 may help protect honey bees from this type of gastrointestinal damage. In field-based studies, supplementing honey bee food with BPC-157 was associated with reduced injury caused by Nosema ceranae in the bee digestive tract, along with improved hive survival rates. [16]

These findings are notable because the studies were conducted in natural field settings rather than only controlled laboratory environments. Researchers suggest that BPC-157 may represent a promising oral research approach for reducing the impact of CCD and supporting honey bee resilience.

Because honey bees are essential pollinators for many food crops, this area of research may have broader importance for pollinator health, agriculture, and ecosystem stability.

Future Directions in BPC-157 Research

BPC-157 remains under active investigation in cell culture and animal research models. It has gained attention not only for its potential role in wound healing and vascular repair, but also as a research tool for better understanding how these biological processes are regulated.

One major area of interest is angiogenesis, the formation of new blood vessels. This process is essential for wound repair and tissue recovery, but it also plays important roles in growth, embryonic development, and cancer biology. Because BPC-157 has been shown to influence vascular growth and tissue-repair pathways, researchers continue to study it as a way to better understand how angiogenesis is controlled.

BPC-157 has also been explored in research related to gastrointestinal protection, connective tissue repair, inflammation regulation, oxidative stress, and medication-related tissue damage. As future studies continue, BPC-157 may help clarify the relationship between blood vessel formation, cellular repair, and long-term tissue recovery.

BPC-157 has demonstrated minimal side effects in mouse studies, along with moderate oral bioavailability and strong subcutaneous bioavailability. However, dosing data from animal studies does not directly translate to humans.

BPC-157 sold by Quant Peptides is intended strictly for educational and scientific research purposes only. It is not for human consumption and should only be purchased by licensed researchers.

Article Author

The above literature was researched, edited and organized by Dr. E. Logan, M.D. Dr. E. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Predrag Sikiric, lead author of “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing”, and co-author of “Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions,” is a Professor of Medical Department at University of Zagreb. Predrag Sikiric is listed in [9] and [16] under the referenced citations.

Predrag Sikiric is being referenced as one of the leading scientists involved in the research and development of BPC-157. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Quant Peptides and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide.

Referenced Citations

1

T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.

2

D. Drmic et al., “Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine,” World J. Gastroenterol., vol. 24, no. 48, pp. 5462–5476, Dec. 2018.

3

F. Amic et al., “Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine,” World J. Gastroenterol., vol. 24, no. 47, pp. 5366–5378, Dec. 2018.

4

A. Duzel et al., “Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights,” World J. Gastroenterol., vol. 23, no. 48, pp. 8465–8488, Dec. 2017.

5

J. Vukojević et al., “Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157,” Vascul. Pharmacol., vol. 106, pp. 54–66, 2018.

6

D. Drmic et al., “Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME,” World J. Gastroenterol., vol. 23, no. 29, pp. 5304–5312, Aug. 2017.

7

M.-J. Hsieh et al., “Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation,” J. Mol. Med. Berl. Ger., vol. 95, no. 3, pp. 323–333, 2017.

8

Z. Grabarevic et al., “The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks,” J. Physiol. Paris, vol. 91, no. 3–5, pp. 139–149, Oct. 1997.

9

P. Sikiric et al., “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1990–2001, 2018.

10

S. Seiwerth et al., “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1972–1989, 2018.

11

C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol., vol. 110, no. 3, pp. 774–780, Oct. 2010.

12

Y.-L. Hu et al., “FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells,” Sci. Rep., vol. 4, p. 6024, Aug. 2014.

13

K. Škrlec et al., “Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities,” Appl. Microbiol. Biotechnol., vol. 102, no. 23, pp. 10103–10117, Dec. 2018.

14

D. Strinic et al., “BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats,” Life Sci., vol. 186, pp. 66–79, Oct. 2017.

15

N. Jelovac et al., “Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats,” Eur. J. Pharmacol., vol. 379, no. 1, pp. 19–31, Aug. 1999.

16

I. Tlak Gajger, J. Ribarić, M. Smodiš Škerl, J. Vlainić, and P. Sikirić, “Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions,” J. Vet. Pharmacol. Ther., vol. 41, no. 4, pp. 614–621, Aug. 2018.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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Storage Instructions:

Storage & Stability

Our peptides are produced using a specialized freeze-drying process known as lyophilization. This process removes moisture from the peptide while preserving its structure, helping maintain stability during storage and shipping.

Before reconstitution, lyophilized peptides are typically presented as a dry, white powder or cake inside the vial. In this form, they are generally more stable than liquid peptides and can better tolerate short-term temperature changes that may occur during transit.

Once received, peptides should be stored in a cool, dry place away from direct light. For short-term storage, refrigeration at approximately 4°C / 39°F is commonly recommended. For longer-term storage, keeping lyophilized peptides frozen may help preserve their stability over time.

After the peptide is reconstituted with bacteriostatic water, it should be stored in the refrigerator and protected from light. Reconstituted peptides are generally recommended for use within 30 days to help maintain quality and stability.

In simple terms:
Lyophilized peptides are designed to remain stable while dry, but once mixed, they should be kept cold and handled with care.

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